Inflammatory CADASIL: the cross-link between CADASIL and multiple sclerosis: a report of two cases and systematic review of the literature - Takeaways - MDSpire
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Inflammatory CADASIL: Exploring the Link Between CADASIL and Multiple Sclerosis Through Two Case Reports and a Comprehensive Literature Review

  • By

  • Ali Mahmoud Ahmed

  • Niraj Mistry

  • Ahmed Samir Gehad

  • Abdelmonem M. Hassan

  • June 5, 2026

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  • 1

    CADASIL is a genetic disorder caused by NOTCH3 gene mutations, leading to vascular dysfunction and various neurological symptoms.

  • 2

    Patients with CADASIL can present with symptoms and MRI findings that mimic multiple sclerosis, complicating diagnosis.

  • 3

    Some cases of CADASIL were initially misdiagnosed as multiple sclerosis due to overlapping clinical and radiological features.

  • 4

    The study reports two cases of patients diagnosed with MS who were later found to have CADASIL, highlighting diagnostic challenges.

  • 5

    A systematic literature review was conducted to explore the relationship between CADASIL and multiple sclerosis, identifying similar cases.

Original Source(s)

Inflammatory CADASIL: the cross-link between CADASIL and multiple sclerosis: a report of two cases and systematic review of the literature

  • by Ali Mahmoud Ahmed, Niraj Mistry, Ahmed Samir Gehad, Abdelmonem M. Hassan

  • June 5, 2026

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