Decoding autoimmune disease with single-cell immune repertoire and transcriptome sequencing: mechanisms and therapeutic opportunities - Takeaways - MDSpire

Decoding autoimmune disease with single-cell immune repertoire and transcriptome sequencing: mechanisms and therapeutic opportunities

  • By

  • Shuqing Wang

  • Zhao Dong

  • Yuefang Liu

  • Xianhe Ren

  • Xin Wang

  • Hongsong Yu

  • June 16, 2026

  • 0 min

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  • 1

    Autoimmune diseases arise from a loss of immune tolerance, leading to the activation of self-reactive T and B cells.

  • 2

    Single-cell T- and B-cell receptor sequencing (scTCR/BCR-seq) enables the analysis of clonal identity and functional states at single-cell resolution.

  • 3

    scTCR/BCR-seq identifies pathogenic clones and elucidates mechanisms like somatic hypermutation and T-B cell interactions in autoimmune diseases.

  • 4

    This technology aids in tracking clonal dynamics, informing prognosis, and predicting responses to targeted therapies in autoimmune conditions.

  • 5

    scTCR/BCR-seq supports the development of antigen-specific tolerance strategies by reconstructing autoantibodies and mapping epitopes.

Original Source(s)

Decoding autoimmune disease with single-cell immune repertoire and transcriptome sequencing: mechanisms and therapeutic opportunities

  • by Shuqing Wang, Zhao Dong, Yuefang Liu, Xianhe Ren, Xin Wang, Hongsong Yu

  • June 16, 2026

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