Gut microbiota-induced elevation of succinate exacerbates diabetic myocardial ischemia/reperfusion injury by promoting macrophage polarization - Takeaways - MDSpire

Gut microbiota-induced elevation of succinate exacerbates diabetic myocardial ischemia/reperfusion injury by promoting macrophage polarization

  • By

  • Yang Wu

  • Juan Dou

  • Min Liu

  • Song Peng

  • Wenyuan Li

  • June 10, 2026

  • 0 min

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  • 1

    Diabetic patients are more susceptible to myocardial ischemia/reperfusion injury due to gut microbiota-derived metabolites.

  • 2

    Succinate accumulation in the heart is linked to gut microbial dysbiosis in diabetic models, affecting macrophage polarization.

  • 3

    Antibiotic-induced depletion of gut microbiota reverses succinate accumulation, highlighting its role as a cardiac metabolite source.

  • 4

    Succinate exacerbates myocardial ischemia/reperfusion injury by polarizing macrophages through the SUCNR1 signaling pathway.

  • 5

    Genetic knockdown of Sucnr1 mitigates the harmful effects of succinate, suggesting a potential therapeutic target in diabetes.

Original Source(s)

Gut microbiota-induced elevation of succinate exacerbates diabetic myocardial ischemia/reperfusion injury by promoting macrophage polarization

  • by Yang Wu, Juan Dou, Min Liu, Song Peng, Wenyuan Li

  • June 10, 2026

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