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At-Home Transcranial Direct Current Stimulation Combined With Gamified Cognitive Control Training for Depression: A Study

  • By

  • Esther Dechantsreiter

  • Frank Padberg

  • Yuval Benjamini

  • Stephan Goerigk

  • Linda Rubene-Kesele

  • Liene Konosonoka

  • Ulrike Vogelmann

  • Tamar Cohen

  • Naamah Lerner

  • Gerrit Burkhardt

  • Aldo Soldini

  • Fabienne Windel

  • Marios Fanourakis

  • Zeno Menestrina

  • Arthur Nguyen

  • Angela Pasqualotto

  • Takuya Morishita

  • Amir Dotan

  • Shira Ahissar

  • Alon Morash

  • Jonas Björklund

  • Lucia Bulubas

  • Daniel Keeser

  • Netta Assa

  • Rémy Gardier

  • Roser Viñals

  • Jean-Philippe Thiran

  • Ronen Segman

  • Omer Bonne

  • Amit Lotan

  • Friedhelm C. Hummel

  • Elmars Rancans

  • Daphne Bavelier

  • Mor Nahum

  • October 19, 2026

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  • 1

    DiSCoVeR was a 6-week, multicenter, double-masked, sham-controlled randomized clinical trial in adults with major depressive disorder.

  • 2

    The trial evaluated the feasibility, safety, and efficacy of combining home-based transcranial direct current stimulation with gamified cognitive control training.

  • 3

    Participants received on-site onboarding before completing the intervention remotely at home.

  • 4

    The study hypothesized that home administration would be feasible and safe and that depressive symptoms would decrease more with double-active treatment than with double-sham control.

  • 5

    Eligible participants were aged 18 to 65 years, had major depressive disorder, and had a 17-item Hamilton Depression Rating Scale score of at least 13.

Original Source(s)

Home Transcranial Direct Current Stimulation With Gamified Cognitive Control Training for Depression: A

  • by Esther Dechantsreiter, Frank Padberg, Yuval Benjamini, Stephan Goerigk, Linda Rubene-Kesele, Liene Konosonoka, Ulrike Vogelmann, Tamar Cohen, Naamah Lerner, Gerrit Burkhardt, Aldo Soldini, Fabienne Windel, Marios Fanourakis, Zeno Menestrina, Arthur Nguyen, Angela Pasqualotto, Takuya Morishita, Amir Dotan, Shira Ahissar, Alon Morash, Jonas Björklund, Lucia Bulubas, Daniel Keeser, Netta Assa, Rémy Gardier, Roser Viñals, Jean-Philippe Thiran, Ronen Segman, Omer Bonne, Amit Lotan, Friedhelm C. Hummel, Elmars Rancans, Daphne Bavelier, Mor Nahum

  • October 19, 2026

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