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Estriol may ease menopause-related cognitive decline
Women reported improvement across 6 cognitive domains during 12 months of estriol-based treatment, while murine models suggested a potential astrocyte-mediated mechanism.
Menopausal women with cognitive decline showed improvements in cognitive symptoms after 12 months of estriol-based hormone treatment.
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The study involved 20 menopausal women with a mean age of 53.5 years receiving daily oral estriol and progesterone as needed.
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Cognitive symptoms were assessed using the Voskuhl Menopause Brain Fog Assessment, revealing significant improvements across all cognitive domains.
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Preclinical assessments in mice indicated that estriol treatment reduced cognitive deficits and glial activation, suggesting a potential mechanism of action.
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The study's limitations include a small sample size, lack of randomization, and reliance on self-reported cognitive changes.
