Estriol may ease menopause-related cognitive decline - Takeaways - MDSpire
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Estriol may ease menopause-related cognitive decline

Women reported improvement across 6 cognitive domains during 12 months of estriol-based treatment, while murine models suggested a potential astrocyte-mediated mechanism.

  • By

  • Andrea Surnit

  • September 3, 2026

  • 3 min

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  • 1

    Menopausal women with cognitive decline showed improvements in cognitive symptoms after 12 months of estriol-based hormone treatment.

  • 2

    The study involved 20 menopausal women with a mean age of 53.5 years receiving daily oral estriol and progesterone as needed.

  • 3

    Cognitive symptoms were assessed using the Voskuhl Menopause Brain Fog Assessment, revealing significant improvements across all cognitive domains.

  • 4

    Preclinical assessments in mice indicated that estriol treatment reduced cognitive deficits and glial activation, suggesting a potential mechanism of action.

  • 5

    The study's limitations include a small sample size, lack of randomization, and reliance on self-reported cognitive changes.

Original Source(s)

Estriol may ease menopause-related cognitive decline

  • by Andrea Surnit

  • September 3, 2026

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