High-resolution mapping of chromatin conformation in HBeAg-treated macrophage provides insights into pathogenesis of HBV-related liver diseases - Takeaways - MDSpire
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Detailed Chromatin Conformation Mapping in HBeAg-Exposed Macrophages Reveals Mechanisms Behind HBV-Associated Liver Disease Pathogenesis

  • By

  • Tiantian Liu

  • Xiaoyu Xie

  • Shujun Ma

  • Huiling Cao

  • Wenwen Wang

  • Zhen Yu

  • Yuemin Feng

  • Jianni Qi

  • Hongjun Bian

  • July 16, 2026

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  • 1

    HBeAg induces macrophage activation and immune tolerance, facilitating HBV immune escape and contributing to liver disease pathogenesis.

  • 2

    The study utilized RNA-seq, Hi-C, and ChIP-seq to analyze the 3D chromatin structure and transcriptional changes in HBeAg-stimulated macrophages.

  • 3

    HBeAg activation led to significant chromatin reorganization, including B-to-A compartment switching and enhancer accumulation, affecting gene expression.

  • 4

    Key genes such as MET, FLNB, and SESN2 were upregulated, while genes like KBTBD11 and BLVRB were downregulated due to chromatin loop disruptions.

  • 5

    The findings provide insights into the epigenetic mechanisms of macrophage dysfunction in HBV-related liver diseases, highlighting potential therapeutic targets.

Original Source(s)

High-resolution mapping of chromatin conformation in HBeAg-treated macrophage provides insights into pathogenesis of HBV-related liver diseases

  • by Tiantian Liu, Xiaoyu Xie, Shujun Ma, Huiling Cao, Wenwen Wang, Zhen Yu, Yuemin Feng, Jianni Qi, Hongjun Bian

  • July 16, 2026

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