Molecular mechanisms of KMT2C alterations in gastrointestinal cancers: enhancer network destabilization, lineage plasticity, and clinical translation - Takeaways - MDSpire

Molecular mechanisms of KMT2C alterations in gastrointestinal cancers: enhancer network destabilization, lineage plasticity, and clinical translation

  • By

  • Xintao Zeng

  • Pei Yang

  • Tao Wang

  • Ruizi Shi

  • Chuan Qin

  • Lun Zhang

  • Ting Jiang

  • Xi Chen

  • Hua Luo

  • Jihong Wei

  • Haiyan Hu

  • Decai Wang

  • Jianjun Wang

  • May 28, 2026

  • 0 min

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  • 1

    KMT2C alterations are prevalent in gastrointestinal cancers, primarily through loss-of-function mutations and structural changes.

  • 2

    KMT2C plays a crucial role in maintaining enhancer integrity, impacting lineage-specific transcriptional programs.

  • 3

    Alterations in KMT2C lead to destabilization of enhancer networks, resulting in significant transcriptional reprogramming.

  • 4

    KMT2C dysfunction affects tumor immune microenvironments, influencing antigenic burden and inflammatory signaling.

  • 5

    KMT2C alterations are linked to tumor mutational burden, microsatellite instability, and responses to immune checkpoint blockade.

Original Source(s)

Molecular mechanisms of KMT2C alterations in gastrointestinal cancers: enhancer network destabilization, lineage plasticity, and clinical translation

  • by Xintao Zeng, Pei Yang, Tao Wang, Ruizi Shi, Chuan Qin, Lun Zhang, Ting Jiang, Xi Chen, Hua Luo, Jihong Wei, Haiyan Hu, Decai Wang, Jianjun Wang

  • May 28, 2026

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