Probiotics' Role in Mitigating Intestinal Mucosal Damage and Dysbiosis in Infants with Congenital Heart Disease Undergoing Cardiopulmonary Bypass - Takeaways - MDSpire

Probiotics' Role in Mitigating Intestinal Mucosal Damage and Dysbiosis in Infants with Congenital Heart Disease Undergoing Cardiopulmonary Bypass

  • By

  • Zhixuan Zhang

  • Xiaoxu Liu

  • Zhaocong Yang

  • Lan Jiang

  • Chengbin Tang

  • Xuming Mo

  • April 24, 2026

  • 0 min

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  • 1

    The study evaluated the impact of probiotics on intestinal health in infants with congenital heart disease undergoing cardiopulmonary bypass.

  • 2

    Probiotics containing Bifidobacterium infantis and Lactobacillus were administered perioperatively to assess their effects on gut microbiota.

  • 3

    Post-surgery, intestinal mucosal barrier function was impaired, indicated by increased levels of IFABP, DAO, D-LA, and CRP.

  • 4

    Probiotic treatment resulted in lower levels of IFABP and DAO, and earlier initiation of enteral feeding compared to the control group.

  • 5

    Probiotics may help alleviate intestinal injury and partially restore microbial diversity after cardiopulmonary bypass in infants.

Original Source(s)

Probiotics' Role in Mitigating Intestinal Mucosal Damage and Dysbiosis in Infants with Congenital Heart Disease Undergoing Cardiopulmonary Bypass

  • by Zhixuan Zhang, Xiaoxu Liu, Zhaocong Yang, Lan Jiang, Chengbin Tang, Xuming Mo

  • April 24, 2026

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