Live Attenuated Measles-Mumps-Rubella and Varicella Vaccinations and Multiple Sclerosis Activity - Takeaways - MDSpire

Live Attenuated Measles-Mumps-Rubella and Varicella Vaccinations and Multiple Sclerosis Activity

  • By

  • René Carvajal

  • Marta Ponzano

  • Carmen Tur

  • Xavier Martínez-Gómez

  • Juliana Esperalba

  • Álvaro Cobo-Calvo

  • Blanca Borras-Bemejo

  • Francesca Bovis

  • Helena Ariño

  • Georgina Arrambide

  • Luca Bollo

  • Joaquín Castilló

  • Manuel Comabella

  • Ingrid Galán

  • Daniel Hernández-Soria

  • Luciana Midaglia

  • Neus Mongay-Ochoa

  • Agustín Pappolla

  • José Alejandro Ramírez

  • José Ángel Rodrigo-Pendás

  • Breogán Rodríguez-Acevedo

  • Jordi Río

  • Ángela Vidal-Jordana

  • Andreu Vilaseca

  • Ana Zabalza

  • Jaume Sastre-Garriga

  • Maria Pia Sormani

  • Xavier Montalban

  • Mar Tintoré

  • Susana Otero-Romero

  • May 20, 2026

  • 0 min

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  • 1

    Vaccination is essential for people with multiple sclerosis (MS), especially before starting immunosuppressive therapies.

  • 2

    Live attenuated vaccines, such as MMR and varicella, are recommended for immunocompetent individuals with MS lacking immunity.

  • 3

    Concerns exist regarding the potential for live attenuated vaccines to trigger inflammatory activity and increase relapse risk in MS patients.

  • 4

    This study aims to evaluate the risk of relapse following MMR or varicella vaccination in individuals with MS using observational data.

  • 5

    The primary endpoint is a noninferiority comparison of relapse activity within one year post-vaccination in the MS cohort.

Original Source(s)

Live Attenuated Measles-Mumps-Rubella and Varicella Vaccinations and Multiple Sclerosis Activity

  • by René Carvajal, Marta Ponzano, Carmen Tur, Xavier Martínez-Gómez, Juliana Esperalba, Álvaro Cobo-Calvo, Blanca Borras-Bemejo, Francesca Bovis, Helena Ariño, Georgina Arrambide, Luca Bollo, Joaquín Castilló, Manuel Comabella, Ingrid Galán, Daniel Hernández-Soria, Luciana Midaglia, Neus Mongay-Ochoa, Agustín Pappolla, José Alejandro Ramírez, José Ángel Rodrigo-Pendás, Breogán Rodríguez-Acevedo, Jordi Río, Ángela Vidal-Jordana, Andreu Vilaseca, Ana Zabalza, Jaume Sastre-Garriga, Maria Pia Sormani, Xavier Montalban, Mar Tintoré, Susana Otero-Romero

  • May 20, 2026

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