BMI-dependent norepinephrine trajectories during vasopressin therapy in septic shock persist independent of weight-normalization and body composition - Takeaways - MDSpire

Norepinephrine Response Patterns During Vasopressin Treatment in Septic Shock Are Influenced by BMI, Regardless of Weight Normalization and Body Composition

  • By

  • Max Melchers

  • Peter Pickkers

  • Arthur Raymond Hubert van Zanten

  • July 17, 2026

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  • 1

    Norepinephrine (NE) response patterns during vasopressin treatment in septic shock are influenced by body mass index (BMI).

  • 2

    Normal weight patients received lower median NE infusion rates compared to obese patients upon vasopressin initiation.

  • 3

    Using absolute NE dosing (mcg/min) revealed persistent BMI-dependent differences in NE trajectories independent of weight normalization.

  • 4

    Body composition metrics like fat-free mass did not significantly alter the association between BMI and NE trajectories after vasopressin initiation.

  • 5

    No significant differences were observed in mean arterial pressure, arterial lactate, or heart rate trajectories across BMI categories after vasopressin initiation.

Original Source(s)

BMI-dependent norepinephrine trajectories during vasopressin therapy in septic shock persist independent of weight-normalization and body composition

  • by Max Melchers, Peter Pickkers, Arthur Raymond Hubert van Zanten

  • July 17, 2026

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