CURE: a phase-based therapeutic framework for chronic inflammation - Takeaways - MDSpire

CURE: a phase-based therapeutic framework for chronic inflammation

  • By

  • Nils Kurzen

  • Stefan Weißinger

  • Hjalmar Kurzen

  • June 15, 2026

  • 0 min

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  • 1

    Chronic inflammation is a key factor in immune-mediated diseases, characterized by self-sustaining inflammatory circuits and cytokine redundancy.

  • 2

    The CURE framework proposes a phase-based therapeutic model focusing on CONTROL, UNLOAD and RESET, and EQUILIBRATE for managing chronic inflammation.

  • 3

    CURE emphasizes durable disease control and relapse prevention by aligning therapeutic intensity with the immune system's dynamic state.

  • 4

    The framework integrates evidence from various immune-mediated conditions, illustrating shared principles for effective disease management.

  • 5

    CURE reframes treatment from reactive symptom suppression to proactive, phase-specific immune stabilization for long-term health.

Original Source(s)

CURE: a phase-based therapeutic framework for chronic inflammation

  • by Nils Kurzen, Stefan Weißinger, Hjalmar Kurzen

  • June 15, 2026

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