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1
Second primary cancers (SPCs) arise from diverse origins, influenced by genetic predisposition, environmental factors, and treatment exposure.
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2
The therapy-conditioned host framework describes how treatment alters the biological state of patients, impacting subsequent cancer risk.
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3
SPCs develop through various pathways, including inherited susceptibility, environmental exposures, and pre-existing somatic mosaicism.
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4
Treatment exposure can lead to mutagenesis and clonal changes in normal tissues, which may differ biologically from pre-treatment conditions.
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5
The proposed model emphasizes the importance of understanding the biological state generated by treatment rather than focusing solely on treatment history.
