Proteomic Profiling Defines Vascular Cell States - Takeaways - MDSpire
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Proteomic Profiling Defines Vascular Cell States

Label-free LC–MS profiles nearly 5,000 cells, resolving smooth muscle subtypes and disease-associated phenotypes 

  • March 18, 2026

  • 2 min

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  • 1

    A label-free single-cell proteomics workflow enables detailed characterization of cell states in complex vascular tissue.

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    Researchers profiled nearly 5,000 individual cells from mouse aortic tissue, quantifying around 500 proteins per cell.

  • 3

    Clustering identified major aortic cell types and distinct smooth muscle cell phenotypes, with some linked to Marfan syndrome.

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    Endothelial cells in Marfan mice showed reduced adhesion proteins and increased smooth muscle-associated proteins.

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    Integrating transcriptomic and proteomic data revealed additional clusters, highlighting potential disease markers.

Original Source(s)

Proteomic Profiling Defines Vascular Cell States

  • March 18, 2026

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