Nutritional Interventions to Boost Immunity and Their Impact on Recovery Following Radical Cystectomy: Results from a Randomized Clinical Study

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Radical cystectomy induces physiological stress, making patients susceptible to infections and muscle loss.
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Enhanced Recovery After Surgery pathways recommend perioperative nutrition to prevent nutritional deficiencies.
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Specialized immunonutrition includes l-arginine, ω-3 fatty acids, and dietary nucleotides, which may mitigate catabolic effects.
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SWOG S1600 is a phase 3 trial comparing specialized immunonutrition to standard oral nutrition support in bladder cancer patients.
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The primary endpoint of the trial is the occurrence of postoperative complications within 30 days of surgery.

Jama Network Open

by Jill M. Hamilton-Reeves, Joseph M. Unger, Jeffrey M. Holzbeierlein, Danika L. Lew, J. Ryan Mark, Siamak Daneshmand, Seth P. Lerner, Janet E. B. Kukreja, Eugene K. Lee, William B. Tabayoyong, Dawn L. Hershman, Michael J. Fisch, N. Lynn Henry
July 20, 2026

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