Patients with major depressive disorder (MDD) exhibited disrupted adult hippocampal neurogenesis, with stalled progression from neural stem-like cells to neuroblasts.
2
Postmortem analysis included hippocampal tissue from 123 patients, with a focus on 19 controls and 11 patients with MDD for multiomic analysis.
3
Pseudotime analysis revealed a shift in cell distribution in MDD patients, showing more quiescent neural stem cells and fewer neuroblasts compared to controls.
4
Molecular alterations in MDD included increased expression of an interferon-related gene module and reduced expression of neurogenesis-related genes in neuroblasts.
5
The study's limitations included its cross-sectional design and challenges in distinguishing MDD-related pathology from suicide-related pathology.
