Trends Over Time and Inequities in Mortality Rates Associated with Co-occurring Atrial Fibrillation and Gastrointestinal Bleeding in the United States, 1999–2020 - Takeaways - MDSpire

Trends Over Time and Inequities in Mortality Rates Associated with Co-occurring Atrial Fibrillation and Gastrointestinal Bleeding in the United States, 1999–2020

  • By

  • Shigang Xu

  • Liwei Duan

  • Yingchuan Zhang

  • Lixue Wu

  • Shuai Jin

  • Linhao Ma

  • January 7, 2026

  • 0 min

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  • 1

    Atrial fibrillation (AF) affects up to 1 in 3 people in their lifetime, with an estimated 15.90 million cases in the US by 2050.

  • 2

    Gastrointestinal bleeding is a major complication of oral anticoagulation therapy for AF, significantly contributing to morbidity and mortality.

  • 3

    From 1999 to 2020, the age-adjusted mortality rate for AF-related gastrointestinal bleeding deaths rose sharply from 0.55 to 1.16 per 100,000.

  • 4

    Males consistently had higher mortality rates from AF-related gastrointestinal bleeding than females, with a more rapid increase observed in males.

  • 5

    Understanding mortality trends related to AF and gastrointestinal bleeding is crucial for guiding preventive strategies and improving clinical practices.

Original Source(s)

Trends Over Time and Inequities in Mortality Rates Associated with Co-occurring Atrial Fibrillation and Gastrointestinal Bleeding in the United States, 1999–2020

  • by Shigang Xu, Liwei Duan, Yingchuan Zhang, Lixue Wu, Shuai Jin, Linhao Ma

  • January 7, 2026

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