The role of intestinal microbiota in the pathogenesis of childhood asthma - Takeaways - MDSpire

The role of intestinal microbiota in the pathogenesis of childhood asthma

  • By

  • Lulu Zhang

  • Li Wu

  • Chunlin Shi

  • Qin Huang

  • Lu Zhan

  • Yan Zeng

  • Quanmin Deng

  • May 8, 2026

  • 0 min

Share

  • 1

    The gut microbiome significantly influences the development of asthma in children by modulating immune responses and T lymphocyte populations.

  • 2

    Microbial dysbiosis in asthmatic children is characterized by reduced beneficial bacteria and increased harmful taxa, impacting immune function.

  • 3

    Microbial metabolites, such as short-chain fatty acids and lipopolysaccharides, play dual roles in either promoting or mitigating airway inflammation.

  • 4

    Disruption of early-life microbial signaling can hinder Th1 development and promote Th2 immunity, increasing childhood asthma risk.

  • 5

    Probiotic supplementation may help restore immune balance by enhancing Treg induction and modulating key immunomodulatory factors.

Original Source(s)

The role of intestinal microbiota in the pathogenesis of childhood asthma

  • by Lulu Zhang, Li Wu, Chunlin Shi, Qin Huang, Lu Zhan, Yan Zeng, Quanmin Deng

  • May 8, 2026

Related Content

Advancements in diagnosis, preventive care, and future directions in the holistic management of pediatric asthma

Laparoscopic intracavitary catheterization combined with bleomycin quadruple sclerotherapy for retroperitoneal lymphatic malformations: a single-center case series

Cardiac and aerobic response to growth hormone therapy in children with short stature: a prospective study using VO2max and speckle tracking echocardiography