Case Report: Adult-onset diffuse hepatic hemangiomatosis with rapid progression: an autopsy case with diagnostic difficulty - Takeaways - MDSpire

Autopsy Findings in a Rare Case of Rapidly Progressive Adult-onset Diffuse Hepatic Hemangiomatosis with Diagnostic Challenges

  • By

  • Takahiro Sugie

  • Rieko Nishimura

  • Yuya Urano

  • Akari Iwakoshi

  • Yoshiko Murakami

  • Mariko Sato

  • Chiyoe Kitagawa

  • Kenichi Harada

  • July 21, 2026

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  • 1

    Diffuse hepatic hemangiomatosis (DHH) is a rare benign vascular liver tumor characterized by infiltrative growth and histological resemblance to hemangiomas.

  • 2

    A 51-year-old female case exhibited rapid progression of hepatic lesions initially suspected to be hemangiomas, leading to diagnostic challenges.

  • 3

    Histopathological evaluation revealed dilated sinusoids lined with endothelial cells, suggesting a benign vascular lesion despite rapid clinical deterioration.

  • 4

    The patient received paclitaxel and durvalumab treatment but showed no therapeutic response and ultimately died from tumor rupture.

  • 5

    Autopsy findings confirmed DHH with multiloculated cystic vascular spaces and pleomorphic endothelial cells, indicating treatment-related artifacts.

Original Source(s)

Case Report: Adult-onset diffuse hepatic hemangiomatosis with rapid progression: an autopsy case with diagnostic difficulty

  • by Takahiro Sugie, Rieko Nishimura, Yuya Urano, Akari Iwakoshi, Yoshiko Murakami, Mariko Sato, Chiyoe Kitagawa, Kenichi Harada

  • July 21, 2026

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