Emerging insights into the role of BDH1 in the pathogenesis of human cancer

1

BDH1 encodes an enzyme crucial for ketone body metabolism, linking β-hydroxybutyrate to acetoacetate, vital during metabolic stress.
2

BDH1 functions as a metabolic rheostat in cancers, influencing energy metabolism, stress resistance, and tumor microenvironment adaptation.
3

Dysregulation of BDH1 is associated with aggressive tumor phenotypes, poor outcomes, and varied responses to cancer therapies.
4

The review highlights BDH1's potential as a prognostic biomarker and therapeutic target in precision oncology.
5

Understanding BDH1's roles in tumorigenesis may improve treatment strategies, including ketogenic diets and mitochondrial-targeted therapies.