Microstructural alterations in brain tissue of ME/CFS and long COVID using diffusion tensor imaging and diffusion kurtosis imaging - Takeaways - MDSpire

Investigating Microstructural Changes in Brain Tissue of ME/CFS and Long COVID through Diffusion Tensor and Kurtosis Imaging Techniques

  • By

  • Tanoj Bahadur Singh

  • Sonya Marshall-Gradisnik

  • Leighton Barnden

  • Natalie Eaton-Fitch

  • Tuong Hieu Huynh

  • Maira Inderyas

  • Kiran Thapaliya

  • July 17, 2026

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  • 1

    This study compares microstructural changes in brain tissue between individuals with ME/CFS and long COVID using DTI and DKI techniques.

  • 2

    Participants included 37 with ME/CFS, 19 with long COVID, and 27 healthy controls, with data acquired using a 3T MRI scanner.

  • 3

    ME/CFS participants exhibited microstructural alterations in the cingulum, supplementary motor areas, and corpus callosum compared to healthy controls.

  • 4

    Long COVID participants showed microstructural changes in the fusiform gyrus, precentral gyrus, and major white matter tracts.

  • 5

    Direct comparisons revealed significant differences in the left corona radiata between ME/CFS and long COVID participants.

Original Source(s)

Microstructural alterations in brain tissue of ME/CFS and long COVID using diffusion tensor imaging and diffusion kurtosis imaging

  • by Tanoj Bahadur Singh, Sonya Marshall-Gradisnik, Leighton Barnden, Natalie Eaton-Fitch, Tuong Hieu Huynh, Maira Inderyas, Kiran Thapaliya

  • July 17, 2026

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