Prognostic significance of coagulation factor activity in acute stroke: a retrospective cohort study - Takeaways - MDSpire

Prognostic significance of coagulation factor activity in acute stroke: a retrospective cohort study

  • By

  • Yunyan Ye

  • Yisha Wang

  • Huan Wang

  • Lei Zhou

  • Shengyi Shi

  • Xuguang Chen

  • May 29, 2026

  • 0 min

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  • 1

    The study analyzed the relationship between coagulation factors VII, IX, XI, and XII and 90-day outcomes in 171 stroke patients.

  • 2

    Hemorrhagic stroke patients were younger and had higher stroke severity and INR levels compared to ischemic stroke patients.

  • 3

    In ischemic stroke, higher FXI and FXII activity correlated with unfavorable prognosis, but these associations were not significant after adjustment.

  • 4

    In hemorrhagic stroke, lower FVII and FIX activity, along with higher FXI and FXII activity, were associated with unfavorable prognosis.

  • 5

    The study highlights the need for phenotype-specific therapeutic interventions based on distinct coagulation factor profiles in stroke.

Original Source(s)

Prognostic significance of coagulation factor activity in acute stroke: a retrospective cohort study

  • by Yunyan Ye, Yisha Wang, Huan Wang, Lei Zhou, Shengyi Shi, Xuguang Chen

  • May 29, 2026

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