Single-cell and spatial omics in non-small cell lung cancer: dissecting metabolic reprogramming and tumor-immune ecosystems for precision pharmacology - Takeaways - MDSpire

Single-cell and spatial omics in non-small cell lung cancer: dissecting metabolic reprogramming and tumor-immune ecosystems for precision pharmacology

  • By

  • Zhenzhen Lian

  • Xu Jing Wu

  • Yangyang Zhou

  • Pengfei Tang

  • Honglei Ge

  • July 6, 2026

  • 0 min

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  • 1

    Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related death, with treatment success varying significantly among patients.

  • 2

    Single-cell and spatial omics provide insights into tumor heterogeneity, metabolic reprogramming, and tumor-immune interactions in NSCLC.

  • 3

    Single-cell RNA sequencing reveals diverse malignant cell states within NSCLC tumors, impacting treatment resistance and relapse.

  • 4

    Metabolic reprogramming in NSCLC involves adjustments in glycolysis, oxidative phosphorylation, and nutrient competition between tumor and immune cells.

  • 5

    The review emphasizes the importance of integrating cell states, metabolic dependencies, and spatial immune architecture for personalized NSCLC therapy.

Original Source(s)

Single-cell and spatial omics in non-small cell lung cancer: dissecting metabolic reprogramming and tumor-immune ecosystems for precision pharmacology

  • by Zhenzhen Lian, Xu Jing Wu, Yangyang Zhou, Pengfei Tang, Honglei Ge

  • July 6, 2026

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