Longitudinal Study of Plasma Metabolites During Menopause and Their Associations With Later Onset of Metabolic Syndrome - Takeaways - MDSpire
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Long-Term Analysis of Plasma Metabolite Changes During Menopause and Their Links to Subsequent Development of Metabolic Syndrome

  • By

  • Atsuko Miyake

  • Miho Iida

  • Sei Harada

  • Daisuke Sugiyama

  • Minako Matsumoto

  • Naoko Miyagawa

  • Ryota Toki

  • Shun Edagawa

  • Aya Hirata

  • Kazuyo Kuwabara

  • Tomonori Okamura

  • Asako Sato

  • Kaori Amano

  • Akiyoshi Hirayama

  • Masahiro Sugimoto

  • Tomoyoshi Soga

  • Masaru Tomita

  • Kazuharu Arakawa

  • Iori Kisu

  • Wataru Yamagami

  • Toru Takebayashi

  • December 13, 2025

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  • 1

    This study analyzed plasma metabolite changes during menopause and their links to metabolic syndrome (MetS) over a mean follow-up of 5 years.

  • 2

    Eighteen metabolites, particularly related to branched-chain amino acids and homocysteine metabolism, changed significantly during menopause.

  • 3

    Of the 695 women without MetS at baseline, 9.4% developed MetS, with glutamate levels significantly associated with higher MetS risk.

  • 4

    Higher levels of glutamate, valine, leucine, and cystine were linked to the development of hyperglycemia in postmenopausal women.

  • 5

    The findings emphasize the importance of monitoring specific metabolites to understand metabolic alterations and risks associated with menopause.

Original Source(s)

Longitudinal Study of Plasma Metabolites During Menopause and Their Associations With Later Onset of Metabolic Syndrome

  • by Atsuko Miyake, Miho Iida, Sei Harada, Daisuke Sugiyama, Minako Matsumoto, Naoko Miyagawa, Ryota Toki, Shun Edagawa, Aya Hirata, Kazuyo Kuwabara, Tomonori Okamura, Asako Sato, Kaori Amano, Akiyoshi Hirayama, Masahiro Sugimoto, Tomoyoshi Soga, Masaru Tomita, Kazuharu Arakawa, Iori Kisu, Wataru Yamagami, Toru Takebayashi

  • December 13, 2025

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