Synergistic TCR-independent action of IL-33 and IL-12 drive a potent IFNγ secretory program in human circulating MAIT cells with immunomodulatory properties - Takeaways - MDSpire

Synergistic TCR-independent action of IL-33 and IL-12 drive a potent IFNγ secretory program in human circulating MAIT cells with immunomodulatory properties

  • By

  • Carlota García-Escribano

  • Maria Gallardo-Jiménez

  • Ana García-Cadarso

  • Paloma Fernández Martínez

  • Ricardo Arroyo-Solera

  • Luis Senador Zaldívar-Martínez

  • Kelin Lin

  • Jeffrey Aubé

  • Patricia Barral

  • Tomás Chivato

  • Domingo Barber

  • Maria M. Escribese

  • Elena Izquierdo

  • Juan Carlos López-Rodríguez

  • June 26, 2026

  • 0 min

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  • 1

    MAIT cells are unconventional T cells that respond rapidly to inflammation, infection, and tissue damage.

  • 2

    IL-33 combined with IL-12p70 induces a strong IFNγ secretion profile in MAIT cells, dependent on p38 MAPK signaling.

  • 3

    Activated MAIT cells secrete various immune mediators, including TNF, VEGF, OSM, CXCL11, and CCL3.

  • 4

    Conditioned media from MAIT cells can polarize CD14+ monocytes towards a proinflammatory M1-like phenotype.

  • 5

    The study highlights the immunomodulatory potential of MAIT cells in influencing diverse immune responses.

Original Source(s)

Synergistic TCR-independent action of IL-33 and IL-12 drive a potent IFNγ secretory program in human circulating MAIT cells with immunomodulatory properties

  • by Carlota García-Escribano, Maria Gallardo-Jiménez, Ana García-Cadarso, Paloma Fernández Martínez, Ricardo Arroyo-Solera, Luis Senador Zaldívar-Martínez, Kelin Lin, Jeffrey Aubé, Patricia Barral, Tomás Chivato, Domingo Barber, Maria M. Escribese, Elena Izquierdo, Juan Carlos López-Rodríguez

  • June 26, 2026

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