Zinc homeostasis dysregulation in elderly patients with acute ischemic stroke: a multidimensional analysis integrating metallothionein, FADS1 activity, oxidative stress, and DNA integrity markers - Takeaways - MDSpire

Zinc homeostasis dysregulation in elderly patients with acute ischemic stroke: a multidimensional analysis integrating metallothionein, FADS1 activity, oxidative stress, and DNA integrity markers

  • By

  • Jing Zhou

  • Qian Zhang

  • Chunmei Wang

  • Tingting Zhao

  • Tongtong Qiu

  • Guojie Xu

  • Cuiying Gu

  • Lihua Yu

  • Zhanyuan Yu

  • May 25, 2026

  • 0 min

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  • 1

    The study evaluated zinc homeostasis dysregulation in 400 elderly participants, including 200 ischemic stroke patients and 200 healthy controls.

  • 2

    Stroke patients showed significantly lower serum zinc and metallothionein-1 levels, alongside elevated FADS1 activity and oxidative DNA damage markers.

  • 3

    Significant alterations in inflammatory and oxidative stress markers were observed in stroke patients compared to controls.

  • 4

    Serum zinc positively correlated with metallothionein-1 and negatively with oxidative DNA damage, indicating potential interrelationships.

  • 5

    A combined biomarker panel demonstrated superior discriminative performance for ischemic stroke compared to individual biomarkers.

Original Source(s)

Zinc homeostasis dysregulation in elderly patients with acute ischemic stroke: a multidimensional analysis integrating metallothionein, FADS1 activity, oxidative stress, and DNA integrity markers

  • by Jing Zhou, Qian Zhang, Chunmei Wang, Tingting Zhao, Tongtong Qiu, Guojie Xu, Cuiying Gu, Lihua Yu, Zhanyuan Yu

  • May 25, 2026

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