High-Dose vs Standard-Dose Influenza Vaccines in Older Adults: A Meta-Analysis - Takeaways - MDSpire

High-Dose vs Standard-Dose Influenza Vaccines in Older Adults: A Meta-Analysis

  • By

  • Kristoffer Grundtvig Skaarup

  • Mats C. H. Lassen

  • Kaveh Hosseini

  • Niklas Dyrby Johansen

  • Matthew M. Loiacono

  • Rebecca C. Harris

  • Sandrine I. Samson

  • Arto A. Palmu

  • Kevin McConeghy

  • Stefan Gravenstein

  • Orly Vardeny

  • Brian Claggett

  • Scott D. Solomon

  • Federico Martinón-Torres

  • Tor Biering-Sørensen

  • May 26, 2026

  • 0 min

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  • 1

    High-dose inactivated influenza vaccine (HD-IIV) contains 60 µg hemagglutinin antigen per strain, four times that of standard-dose inactivated influenza vaccine (SD-IIV).

  • 2

    HD-IIV has shown a relative vaccine efficacy of 24.2% compared to SD-IIV in preventing laboratory-confirmed influenza in adults aged 65 and older.

  • 3

    The FLUNITY-HD study demonstrated that HD-IIV provides superior protection against hospitalizations for pneumonia, cardiorespiratory disease, and all causes compared to SD-IIV.

  • 4

    A meta-analysis including 105,685 participants indicated that HD-IIV is associated with reduced hospitalizations for pneumonia or influenza compared to SD-IIV.

  • 5

    The meta-analysis aimed to summarize findings from randomized trials comparing HD-IIV and SD-IIV for preventing severe clinical outcomes in older adults.

Original Source(s)

High-Dose vs Standard-Dose Influenza Vaccines in Older Adults: A Meta-Analysis

  • by Kristoffer Grundtvig Skaarup, Mats C. H. Lassen, Kaveh Hosseini, Niklas Dyrby Johansen, Matthew M. Loiacono, Rebecca C. Harris, Sandrine I. Samson, Arto A. Palmu, Kevin McConeghy, Stefan Gravenstein, Orly Vardeny, Brian Claggett, Scott D. Solomon, Federico Martinón-Torres, Tor Biering-Sørensen

  • May 26, 2026

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