Establishment and optimization of an E. coli urinary tract infection model in Göttingen minipigs with strain recovery and characterization - Takeaways - MDSpire

Establishment and optimization of an E. coli urinary tract infection model in Göttingen minipigs with strain recovery and characterization

  • By

  • Joyce Lübbers

  • Kaila Orlandini

  • Emily Podob

  • Jeffrey Fernandez

  • Jolaine M Wilson

  • Marjolein van Heerden

  • Jeroen Zeijpveld

  • Joan van Kregten

  • Peter T. Buckley

  • Germie van den Dobbelsteen

  • Kirsten L. Bair

  • May 18, 2026

  • 0 min

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  • 1

    A novel urinary tract infection model using Göttingen minipigs was established to study uropathogenic E. coli (UPEC) infections.

  • 2

    The intraurethral challenge with UPEC strain UTI89 successfully established infection in minipigs for 14 days.

  • 3

    Strain analysis revealed that 75% of infected minipigs retained the UTI89 strain, while 25% had different E. coli strains.

  • 4

    Careful verification of bacterial strains is crucial for accurate evaluation of UTI treatment and vaccine efficacy.

  • 5

    This minipig model enhances the translational relevance of UTI research, bridging preclinical findings to human clinical outcomes.

Original Source(s)

Establishment and optimization of an E. coli urinary tract infection model in Göttingen minipigs with strain recovery and characterization

  • by Joyce Lübbers, Kaila Orlandini, Emily Podob, Jeffrey Fernandez, Jolaine M Wilson, Marjolein van Heerden, Jeroen Zeijpveld, Joan van Kregten, Peter T. Buckley, Germie van den Dobbelsteen, Kirsten L. Bair

  • May 18, 2026

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