Diagnostic efficacy of ([Ca]×[Cl])/P combined with ALP in the diagnosis and subtype differentiation of primary hyperparathyroidism

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The study evaluated the diagnostic performance of the calcium-chloride/phosphorus ratio and alkaline phosphatase in primary hyperparathyroidism.
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A total of 135 patients with primary hyperparathyroidism were analyzed, including 77 with hypercalcemic and 58 with normocalcemic subtypes.
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The combination of calcium-chloride/phosphorus ratio and alkaline phosphatase showed high sensitivity (94.8%) and specificity (98.5%) for diagnosing primary hyperparathyroidism.
4

The area under the ROC curve for the combined diagnostic indicators was 0.983, indicating superior performance compared to parathyroid hormone alone.
5

This study highlights the clinical utility of combining these biochemical markers for differentiating subtypes of primary hyperparathyroidism.

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