A longitudinal study on the correlation between faecal urease activity and incidence of nappy rash in infants - Takeaways - MDSpire

A longitudinal study on the correlation between faecal urease activity and incidence of nappy rash in infants

  • By

  • Krystal A. Le Doaré

  • Vicky Hunt

  • Robyn Deeks

  • Amanda Vick

  • A. Toby. A. Jenkins

  • May 25, 2026

  • 0 min

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  • 1

    Nappy rash affects 70% of infants within their first 24 months, causing discomfort and stress for both infants and parents.

  • 2

    This study investigates the correlation between faecal urease levels and the incidence of nappy rash in infants over 9 months.

  • 3

    Statistical analysis revealed a significant correlation between urease activity and nappy rash incidence (P = <0.0002).

  • 4

    Urease catalyzes ammonia production, damaging skin barrier function and creating a pH environment conducive to opportunistic infections.

  • 5

    This research provides the first population-level evidence linking faecal enzyme activity to the occurrence of nappy rash.

Original Source(s)

A longitudinal study on the correlation between faecal urease activity and incidence of nappy rash in infants

  • by Krystal A. Le Doaré, Vicky Hunt, Robyn Deeks, Amanda Vick, A. Toby. A. Jenkins

  • May 25, 2026

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