Evaluating the Diagnostic Potential of Gut Microbiota Analysis and Blood Biomarkers for Predicting Post-Stroke Infections in Acute Ischemic Stroke Patients - Takeaways - MDSpire

Evaluating the Diagnostic Potential of Gut Microbiota Analysis and Blood Biomarkers for Predicting Post-Stroke Infections in Acute Ischemic Stroke Patients

  • By

  • Weny Rinawati

  • Aryati Aryati

  • Abdulloh Machin

  • Stefan Kiechl

  • Gregor Broessner

  • April 28, 2026

  • 0 min

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  • 1

    Post-stroke infections (PSI) are common complications after acute ischemic stroke (AIS), significantly impacting patient outcomes.

  • 2

    NMDAR was identified as the most effective biomarker for predicting PSI, with an AUC of 0.911, sensitivity of 86.5%, and specificity of 90.7%.

  • 3

    Gut microbiota analysis showed reduced diversity and an imbalance in pathogenic and beneficial bacteria in patients with PSI.

  • 4

    Combining gut microbiota profiling with circulating biomarkers improved diagnostic accuracy for predicting PSI compared to single biomarker approaches.

  • 5

    The study underscores the importance of the gut–brain–immune axis in post-stroke complications and supports integrated models for risk assessment.

Original Source(s)

Evaluating the Diagnostic Potential of Gut Microbiota Analysis and Blood Biomarkers for Predicting Post-Stroke Infections in Acute Ischemic Stroke Patients

  • by Weny Rinawati, Aryati Aryati, Abdulloh Machin, Stefan Kiechl, Gregor Broessner

  • April 28, 2026

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