Opposing gastric and jejunal regulation of CELA2A in obesity and after Roux-en-Y gastric bypass suggests a role in gastrointestinal metabolic signaling - Takeaways - MDSpire

Differential Regulation of CELA2A in the Stomach and Jejunum During Obesity and Post-Roux-en-Y Gastric Bypass Indicates Its Involvement in Gastrointestinal Metabolic Signaling

  • By

  • Carl I. W. Larson

  • Melania Aluia

  • Eric Schéle

  • Suzanne L. Dickson

  • Anna Casselbrant

  • Ville Wallenius

  • May 25, 2026

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  • 1

    CELA2A expression increases in gastric mucosa but decreases in the jejunum after Roux-en-Y gastric bypass (RYGB).

  • 2

    Before RYGB, jejunal CELA2A levels correlate positively with HbA1c, indicating a potential role in glucose metabolism.

  • 3

    In high-fat diet-fed mice, jejunal CELA2A expression rises while gastric expression declines, suggesting dietary influence on regulation.

  • 4

    CELA2A is implicated in gastrointestinal metabolic signaling, highlighting its potential role beyond being a digestive enzyme.

  • 5

    Further studies are needed to clarify CELA2A's cellular origin and its functional role in glucose homeostasis post-surgery.

Original Source(s)

Opposing gastric and jejunal regulation of CELA2A in obesity and after Roux-en-Y gastric bypass suggests a role in gastrointestinal metabolic signaling

  • by Carl I. W. Larson, Melania Aluia, Eric Schéle, Suzanne L. Dickson, Anna Casselbrant, Ville Wallenius

  • May 25, 2026

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