Metabolism of myeloid cells in brain tumors - Takeaways - MDSpire

Metabolism of myeloid cells in brain tumors

  • By

  • Aashna Saxena

  • Defne Bayik

  • July 14, 2026

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  • 1

    Glioblastoma (GBM) is a highly aggressive brain tumor with a low 5-year survival rate and limited treatment options.

  • 2

    Myeloid cells constitute up to 30% of the tumor mass in GBM, indicating their significant role in tumor progression.

  • 3

    The GBM tumor microenvironment (TME) induces metabolic reprogramming in myeloid cells, contributing to immunosuppression.

  • 4

    Distinct myeloid populations localize to specific tumor niches, reinforcing regional metabolic programs within the TME.

  • 5

    The review discusses the implications of immunometabolic reprogramming in GBM heterogeneity and treatment resistance.

Original Source(s)

Metabolism of myeloid cells in brain tumors

  • by Aashna Saxena, Defne Bayik

  • July 14, 2026

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