Longitudinal dynamics of symptom networks in patients with differentiated thyroid cancer undergoing radioactive iodine therapy: a prospective cohort study - Takeaways - MDSpire

Longitudinal dynamics of symptom networks in patients with differentiated thyroid cancer undergoing radioactive iodine therapy: a prospective cohort study

  • By

  • Juan Deng

  • Qin Deng

  • Li Zhang

  • April 30, 2026

  • 0 min

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  • 1

    This study enrolled 520 differentiated thyroid cancer patients to analyze symptom networks during radioactive iodine therapy.

  • 2

    Significant changes in symptom network structure were observed across three timepoints: pre-treatment, post-treatment, and one week after discharge.

  • 3

    Psychological distress consistently exhibited the highest strength centrality and bridge strength across all timepoints during treatment.

  • 4

    Throat/mouth symptoms emerged as critical bridge symptoms connecting physical and psychological symptom clusters after RAI therapy.

  • 5

    The findings suggest a need for psychological interventions during the treatment-to-surveillance transition for improved symptom management.

Original Source(s)

Longitudinal dynamics of symptom networks in patients with differentiated thyroid cancer undergoing radioactive iodine therapy: a prospective cohort study

  • by Juan Deng, Qin Deng, Li Zhang

  • April 30, 2026

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