Spatial organization of the tumor immune microenvironment in LAR+ triple-negative breast cancer - Takeaways - MDSpire

Spatial organization of the tumor immune microenvironment in LAR+ triple-negative breast cancer

  • By

  • Donatella Lucchetti

  • Alba Di Leone

  • Giulia Sabbatinelli

  • Federica Toma

  • Franco Antonio

  • Beatrice Cellini

  • Filomena Colella

  • Erica Pazzaglia

  • Chiara Parrillo

  • Luciano Giacó

  • Angela Santoro

  • Alessia Piermattei

  • Rita Colonna

  • Gianluca Franceschini

  • Alessandro Sgambato

  • May 22, 2026

  • 0 min

Share

  • 1

    LAR+ TNBC is a subtype of triple-negative breast cancer characterized by lower proliferative activity and reduced chemotherapy sensitivity.

  • 2

    The study utilized multiplex immunofluorescence to analyze immune and tumor cell subtypes in LAR+ TNBC pre- and post-neoadjuvant therapy.

  • 3

    Patients achieving pathological complete response (pCR) had higher pre-treatment densities of specific immune subsets compared to non-responders.

  • 4

    Spatial analysis revealed distinct immune microenvironment patterns between responders and non-responders after neoadjuvant therapy.

  • 5

    The findings suggest that immune enrichment and spatial dynamics differ in LAR+ TNBC, highlighting the need for further research in larger cohorts.

Original Source(s)

Spatial organization of the tumor immune microenvironment in LAR+ triple-negative breast cancer

  • by Donatella Lucchetti, Alba Di Leone, Giulia Sabbatinelli, Federica Toma, Franco Antonio, Beatrice Cellini, Filomena Colella, Erica Pazzaglia, Chiara Parrillo, Luciano Giacó, Angela Santoro, Alessia Piermattei, Rita Colonna, Gianluca Franceschini, Alessandro Sgambato

  • May 22, 2026

Related Content

MRI perfusion in evaluating ovarian masses: diagnostic performance of wash out rate

Artificial intelligence for optimization of immunotherapy: current applications and transformative potential

Icaritin plus TACE improves survival in advanced HCC with macrovascular invasion: a multicenter cohort study