Demonstrating the reliability of in vivo metabolomics-based chemical grouping: Part 2 – Consistency of group-specific metabolic effects - Takeaways - MDSpire
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Assessing the Reliability of In Vivo Metabolomics-Based Chemical Grouping: Part 2—Consistency of Metabolic Effects Within Groups

  • By

  • G. R. Lloyd

  • C. Sands

  • A. Kende

  • V. Haake

  • E. Amstalden

  • M. Bouhifd

  • T. Ebbels

  • F. Lai

  • P. E.G. Leonards

  • U. Simanainen

  • T. Sobanski

  • A. D. Southam

  • L. Swindale

  • R. J. M. Weber

  • F. M. Zickgraf

  • H. Kamp

  • M. R. Viant

  • October 7, 2026

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  • 1

    The MATCHING ring trial previously found that partners consistently assigned eight chemicals to three effect groups using in vivo metabolomics.

  • 2

    This study assessed whether metabolic responses within the androgen receptor activity, peroxisome proliferation, and anaemia groups were consistent across five partners.

  • 3

    The study also evaluated whether discriminatory metabolite profiles could be interpreted using literature- and database-derived metabolomic associative key events.

  • 4

    The analysis considered female and male rats separately and aimed to improve detection specificity by combining toxicological knowledge with reproducibility in metabolite detection and directional cha

  • 5

    The authors proposed that enrichment for characteristic metabolomic associative key events could provide a plausible interpretation when concordant with the adverse outcome hypothesis.

Original Source(s)

Demonstrating the reliability of in vivo metabolomics-based chemical grouping: Part 2 – Consistency of group-specific metabolic effects

  • by G. R. Lloyd, C. Sands, A. Kende, V. Haake, E. Amstalden, M. Bouhifd, T. Ebbels, F. Lai, P. E.G. Leonards, U. Simanainen, T. Sobanski, A. D. Southam, L. Swindale, R. J. M. Weber, F. M. Zickgraf, H. Kamp, M. R. Viant

  • October 7, 2026

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