Transcriptomic signatures and immune microenvironment of acute rejection after heart transplantation: an integrated bioinformatics analysis - Takeaways - MDSpire

Transcriptomic signatures and immune microenvironment of acute rejection after heart transplantation: an integrated bioinformatics analysis

  • By

  • Wenjun Zhou

  • Langjing Huang

  • Wenwen Tang

  • May 25, 2026

  • 0 min

Share

  • 1

    The study analyzed gene expression profiles from endomyocardial biopsy samples to understand acute heart transplant rejection.

  • 2

    A total of 1,032 genes were differentially expressed between acute rejection and non-rejection samples, with significant immune activation observed.

  • 3

    Key pathways enriched in rejection included interferon signaling, T-cell receptor signaling, and antigen presentation.

  • 4

    The diagnostic model developed demonstrated strong performance with an AUC of 0.993, indicating high accuracy in distinguishing rejection.

  • 5

    Experimental validation confirmed the upregulation of interferon-related and cytotoxic genes in transplanted grafts during acute rejection.

Original Source(s)

Transcriptomic signatures and immune microenvironment of acute rejection after heart transplantation: an integrated bioinformatics analysis

  • by Wenjun Zhou, Langjing Huang, Wenwen Tang

  • May 25, 2026

Related Content

Functional consequences of diminished myocardial oxygen delivery per beat in experimental heart failure

Recognizing the Transition to Advanced Heart Failure Earlier

Despite major advances in guideline-directed medical therapy (GDMT), worsening heart failure continues to drive significant morbidity, repeat hospitalizations and healthcare utilization worldwide.

  • by

  • May 27, 2026

  • 6 min
Lipoprotein(a) and Risk of Treated Ventricular Arrhythmias in Heart Failure