PON1 haplotypes show genotype-dependent associations with dysglycemia and metabolic liver risk beyond paraoxonase activity - Takeaways - MDSpire

PON1 haplotypes show genotype-dependent associations with dysglycemia and metabolic liver risk beyond paraoxonase activity

  • By

  • Laura Batista-Herrera

  • Maria João Meneses

  • Rogério T. Ribeiro

  • Luís Gardete-Correia

  • João F. Raposo

  • José Manuel Boavida

  • Carlos Penha-Gonçalves

  • Maria Paula Macedo

  • July 7, 2026

  • 0 min

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  • 1

    Two independent PON1 variants, rs2057681 and rs854572, are major determinants of paraoxonase activity.

  • 2

    Haplotype analysis showed that genetic configurations of PON1 variants are associated with dysglycemia and metabolic liver risk.

  • 3

    In carriers of the rs2057681 G allele, the C–A haplotype was linked to lower dysglycemia risk and higher Fibrotic NASH Index.

  • 4

    The same C–A haplotype in rs2057681 AA homozygotes was associated with increased metabolic liver risk.

  • 5

    PON1 genetic architecture influences metabolic risk beyond enzyme activity, highlighting the complexity of its role in cardiometabolic disease.

Original Source(s)

PON1 haplotypes show genotype-dependent associations with dysglycemia and metabolic liver risk beyond paraoxonase activity

  • by Laura Batista-Herrera, Maria João Meneses, Rogério T. Ribeiro, Luís Gardete-Correia, João F. Raposo, José Manuel Boavida, Carlos Penha-Gonçalves, Maria Paula Macedo

  • July 7, 2026

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