Exploring the Shared Genetic Basis of Age at Menopause and Osteoarthritis - Takeaways - MDSpire

Investigating the Common Genetic Factors Linking Menopause Onset and Osteoarthritis

  • By

  • Bingru Luo

  • Lili Huang

  • Jing Zhou

  • Panpan Long

  • July 1, 2026

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  • 1

    Osteoarthritis (OA) prevalence has increased significantly from 1990 to 2020, largely due to population growth and aging.

  • 2

    Estrogen plays a protective role in joint health, and its decline after menopause increases the risk of developing OA in women.

  • 3

    Genome-wide association studies (GWAS) have identified genetic loci linked to both OA susceptibility and the age at menopause.

  • 4

    Linkage disequilibrium score regression (LDSC) was used to analyze genetic correlations between OA and menopause age.

  • 5

    Pleiotropic analysis under composite null hypothesis (PLACO) was employed to identify SNPs associated with both OA and menopause age.

Original Source(s)

Exploring the Shared Genetic Basis of Age at Menopause and Osteoarthritis

  • by Bingru Luo, Lili Huang, Jing Zhou, Panpan Long

  • July 1, 2026

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