Orosomucoid 2 (ORM2) in type 2 diabetes and coronary artery disease: a potential link between insulin resistance and vascular inflammation

1

Orosomucoid 2 (ORM2) is a hepatocyte-derived glycoprotein linked to metabolic and vascular dysfunction in type 2 diabetes and coronary artery disease.
2

Reduced ORM2 expression is associated with obesity and insulin resistance, impacting hepatic lipid metabolism and insulin sensitivity.
3

ORM2 regulates glucose homeostasis and macrophage polarization, highlighting its role in the inflammation and metabolism interface.
4

Circulating ORM2 levels correlate with diabetic nephropathy and myocardial infarction risk, suggesting its potential as a biomarker.
5

Further research is needed to clarify ORM2's role in the shared pathophysiology of type 2 diabetes and coronary artery disease.

1