Exploring the Influence of Genetic Vulnerability to Neurodevelopmental Disorders on Antipsychotic Efficacy in Schizophrenia: Insights from a Postmortem Brain Analysis - Takeaways - MDSpire

Exploring the Influence of Genetic Vulnerability to Neurodevelopmental Disorders on Antipsychotic Efficacy in Schizophrenia: Insights from a Postmortem Brain Analysis

  • By

  • Kazusa Miyahara

  • Mizuki Hino

  • Risa Shishido

  • Atsuko Nagaoka

  • Hideomi Hamasaki

  • Akiyoshi Kakita

  • Hiroaki Tomita

  • Yasuto Kunii

  • April 27, 2026

  • 0 min

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  • 1

    Schizophrenia is a highly heritable disorder with overlapping genomic architecture with neurodevelopmental disorders like ADHD and ASD.

  • 2

    The study analyzed postmortem brain samples to assess the impact of ADHD and ASD genetic risks on schizophrenia symptoms and antipsychotic responsiveness.

  • 3

    A suggestive negative correlation was found between antipsychotic responsiveness for positive symptoms and ADHD-PRS, while a positive correlation was noted with ASD-PRS.

  • 4

    Gene expression analysis revealed 1,773 differentially expressed genes related to neuropsychiatric disorders, enriched in neuronal and mitochondrial pathways.

  • 5

    The findings suggest that genetic risks for neurodevelopmental disorders may influence antipsychotic responsiveness in schizophrenia, warranting further research.

Original Source(s)

Exploring the Influence of Genetic Vulnerability to Neurodevelopmental Disorders on Antipsychotic Efficacy in Schizophrenia: Insights from a Postmortem Brain Analysis

  • by Kazusa Miyahara, Mizuki Hino, Risa Shishido, Atsuko Nagaoka, Hideomi Hamasaki, Akiyoshi Kakita, Hiroaki Tomita, Yasuto Kunii

  • April 27, 2026

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