Investigating Metabolic and Inflammatory Patterns in Staging Cardiovascular-Kidney-Metabolic Syndrome: A Comparative Cross-Sectional Analysis - Takeaways - MDSpire

Investigating Metabolic and Inflammatory Patterns in Staging Cardiovascular-Kidney-Metabolic Syndrome: A Comparative Cross-Sectional Analysis

  • By

  • Teng Zhang

  • Zi-Yue Man

  • Shi-Meng Zhang

  • Jian-Jun Mu

  • Yue-Yuan Liao

  • April 22, 2026

  • 0 min

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  • 1

    This study investigates metabolic and inflammatory patterns in cardiovascular-kidney-metabolic syndrome across Chinese and U.S. adults.

  • 2

    Insulin resistance/dyslipidemia pathological score (IRD-PS) is strongly associated with established CKM status in both populations studied.

  • 3

    Systemic low-grade inflammation pathological score (SLI-PS) correlates significantly with advanced CKM status in both Shaanxi and NHANES.

  • 4

    The study reveals significant racial/ethnic heterogeneity in the association between IRD-PS and established CKM status in the NHANES cohort.

  • 5

    Findings suggest metabolic dysregulation is linked to established CKM status, while systemic inflammation is more relevant for advanced CKM status.

Original Source(s)

Investigating Metabolic and Inflammatory Patterns in Staging Cardiovascular-Kidney-Metabolic Syndrome: A Comparative Cross-Sectional Analysis

  • by Teng Zhang, Zi-Yue Man, Shi-Meng Zhang, Jian-Jun Mu, Yue-Yuan Liao

  • April 22, 2026

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