GLA is associated with ESCC progression and chemotherapy response via DNA damage repair–related pathways - Takeaways - MDSpire

GLA is associated with ESCC progression and chemotherapy response via DNA damage repair–related pathways

  • By

  • Ke Chen

  • Qinsong Yang

  • Chen Fang

  • Weiran Zhang

  • Yu Feng

  • Haitao Ma

  • July 15, 2026

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  • 1

    GLA is significantly upregulated in esophageal squamous cell carcinoma (ESCC) and shows strong diagnostic performance across multiple datasets.

  • 2

    GLA overexpression in ESCC is confirmed through immunohistochemistry, qRT-PCR, and Western blot analyses.

  • 3

    Knockdown of GLA suppresses proliferation, colony formation, and migration of ESCC cells, indicating its oncogenic role.

  • 4

    High GLA expression is associated with DNA damage repair and chemoresistance-related genes, impacting chemotherapy efficacy.

  • 5

    Combining the GLA pharmacological chaperone Migalastat with gemcitabine or cisplatin enhances cytotoxicity in ESCC cell lines.

Original Source(s)

GLA is associated with ESCC progression and chemotherapy response via DNA damage repair–related pathways

  • by Ke Chen, Qinsong Yang, Chen Fang, Weiran Zhang, Yu Feng, Haitao Ma

  • July 15, 2026

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