Top 10 evidence-based essentials in rheumatology

A structured framework of guidelines, trials, therapies, and tools used in clinical practice

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EULAR rheumatoid arthritis recommendations favor initial methotrexate, ideally with short-term glucocorticoids, and adding a biologic DMARD if response is insufficient after 3 to 6 months.
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ACR guidance for systemic lupus erythematosus highlights hydroxychloroquine, limiting glucocorticoid duration, and early immunosuppressive therapy to achieve and maintain remission or low disease acti
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ACR gout guidance recommends allopurinol as first-line urate-lowering therapy when indicated, dose titration to a serum urate target below 6 mg/dL, and anti-inflammatory prophylaxis for at least 3 to
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In ORAL Surveillance, tofacitinib did not meet noninferiority criteria versus tumor necrosis factor inhibitors for major cardiovascular events or cancers excluding nonmelanoma skin cancer.
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ACR identifies 5 preferred rheumatoid arthritis disease activity measures, while FRAX estimates 10-year hip and major osteoporotic fracture probabilities using clinical risk factors and femoral neck b

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