Internet-based indicated prevention of anxiety and depression disorder onset three-arm randomized clinical trial - Takeaways - MDSpire

Internet-based indicated prevention of anxiety and depression disorder onset three-arm randomized clinical trial

  • By

  • Anna-Carlotta Zarski

  • Kiona K. Weisel

  • Thomas Berger

  • Tobias Krieger

  • Michael P. Schaub

  • Matthias Berking

  • Dennis Görlich

  • Corinna Jacobi

  • Rosa Baños

  • Cristina Botella

  • Rocio Herrero

  • David D. Ebert

  • October 1, 2025

  • 0 min

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  • 1

    The study evaluated internet-based prevention for anxiety and depression in 566 adults with subthreshold symptoms.

  • 2

    Participants were assigned to individually guided, automatically guided, or waitlist control groups over 12 months.

  • 3

    The individually guided intervention had a 19.4% onset of anxiety/depression, while the automated group had 14.8%, compared to 30.9% in the control.

  • 4

    Cumulative incidence rates were significantly lower in both intervention groups compared to the waitlist control, indicating effective prevention.

  • 5

    Both guided interventions demonstrated reduced incidence of anxiety and depressive disorders, supporting the efficacy of internet-based prevention.

Original Source(s)

Internet-based indicated prevention of anxiety and depression disorder onset three-arm randomized clinical trial

  • by Anna-Carlotta Zarski, Kiona K. Weisel, Thomas Berger, Tobias Krieger, Michael P. Schaub, Matthias Berking, Dennis Görlich, Corinna Jacobi, Rosa Baños, Cristina Botella, Rocio Herrero, David D. Ebert

  • October 1, 2025

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