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1
Adolescence is a dual-sensitive period marked by concurrent brain and gut microbiota maturation, increasing vulnerability to depression.
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2
The prevalence of adolescent depression has surged from 8.1% to 15.8% between 2009 and 2019, exacerbated by the COVID-19 pandemic.
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3
Dysregulated gut-brain communication during adolescence may lead to neuroinflammation and altered metabolism, contributing to depression.
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4
Current antidepressant treatments, including SSRIs, show limited efficacy and safety concerns in adolescents, highlighting the need for novel interventions.
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5
Microbiota-targeted interventions show promise in addressing adolescent depression, suggesting a link between gut dysbiosis and depressive symptoms.
