Results of a Third Round of Salvage Spine Stereotactic Radiosurgery for Spinal Metastases: A Case Series from a Single Institution

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Salvage spine stereotactic radiosurgery (sSRS) effectively re-irradiates spinal metastases with a 1-year local control rate of approximately 80%.
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This study analyzed 10 spinal metastases in 6 patients who underwent a third course of sSRS after radiographic progression.
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The median interval between sSRS treatments was 12.1 months, indicating a significant time for potential tumor regrowth.
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Radiographic failure was defined as progression on imaging, assessed by a multidisciplinary team including radiology and oncology.
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Future studies should incorporate SPINO criteria for response assessment in patients receiving multiple sSRS courses.

Journal Of Neuro-Oncology (Springer)

by Jessica J. Bai, Ehsan H. Balagamwala, Anthony Magnelli, Lilyana Angelov, John H. Suh, Erin S. Murphy, Praveen Pendyala, Samuel T. Chao
April 22, 2026

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