Phytomedicines in preclinical and clinical research on antipsychotics-induced EPS/EPS-like behaviors: therapeutic effects and neurobiological mechanisms - Takeaways - MDSpire

Phytomedicines in preclinical and clinical research on antipsychotics-induced EPS/EPS-like behaviors: therapeutic effects and neurobiological mechanisms

  • By

  • Ziwen Wang

  • Huicong Shi

  • Chengbin Guan

  • Xin-Min Li

  • Haiyun Xu

  • June 19, 2026

  • 0 min

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  • 1

    Extrapyramidal syndrome (EPS) is a movement disorder caused by dysfunction of the extrapyramidal system, often due to antipsychotic drug use.

  • 2

    Chronic use of antipsychotic drugs can lead to various EPS phenotypes, including acute dystonia, akathisia, pseudoparkinsonism, and tardive dyskinesia.

  • 3

    Herbal medicines have shown potential in preventing and treating EPS induced by antipsychotics, with several studies reporting beneficial effects.

  • 4

    The therapeutic effects of herbal medicines involve mechanisms such as regulating neurotransmission, alleviating oxidative stress, and suppressing neuroinflammation.

  • 5

    A comprehensive literature review identified various herbal formulas and phytochemicals that may improve EPS or EPS-like behaviors in clinical and preclinical studies.

Original Source(s)

Phytomedicines in preclinical and clinical research on antipsychotics-induced EPS/EPS-like behaviors: therapeutic effects and neurobiological mechanisms

  • by Ziwen Wang, Huicong Shi, Chengbin Guan, Xin-Min Li, Haiyun Xu

  • June 19, 2026

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