Herbal Medicines in the Prevention and Treatment of Antipsychotic-Induced Extrapyramidal Symptoms: Insights from Preclinical and Clinical Studies

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Extrapyramidal syndrome (EPS) is a movement disorder caused by dysfunction of the extrapyramidal system, often due to antipsychotic drug use.
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Chronic use of antipsychotic drugs can lead to various EPS phenotypes, including acute dystonia, akathisia, pseudoparkinsonism, and tardive dyskinesia.
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Herbal medicines have shown potential in preventing and treating EPS induced by antipsychotics, with several studies reporting beneficial effects.
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The therapeutic effects of herbal medicines involve mechanisms such as regulating neurotransmission, alleviating oxidative stress, and suppressing neuroinflammation.
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A comprehensive literature review identified various herbal formulas and phytochemicals that may improve EPS or EPS-like behaviors in clinical and preclinical studies.

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