TyG-WHtR predicts incident type 2 diabetes mellitus in NAFLD: a 12-year prospective cohort study - Takeaways - MDSpire

TyG-WHtR predicts incident type 2 diabetes mellitus in NAFLD: a 12-year prospective cohort study

  • By

  • Nan’nan Chen

  • Jiang Li

  • Gang Li

  • Faming Zhao

  • May 1, 2026

  • 0 min

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  • 1

    The study evaluated twelve metabolic composite indices for predicting type 2 diabetes mellitus (T2DM) in patients with nonalcoholic fatty liver disease (NAFLD).

  • 2

    The triglyceride–glucose–waist–height ratio (TyG-WHtR) showed a significant hazard ratio of 1.77 for T2DM onset among NAFLD patients over 12 years.

  • 3

    All twelve indices demonstrated a linear relationship with T2DM onset, indicating their potential as predictive tools in NAFLD patients.

  • 4

    The TyG-WHtR exhibited the highest predictive accuracy with an area under the curve (AUC) of 0.680, although not statistically superior to TyG-WC.

  • 5

    Identifying NAFLD patients at high risk for T2DM is crucial for early intervention, given the severe health implications associated with both conditions.

Original Source(s)

TyG-WHtR predicts incident type 2 diabetes mellitus in NAFLD: a 12-year prospective cohort study

  • by Nan’nan Chen, Jiang Li, Gang Li, Faming Zhao

  • May 1, 2026

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