Several antiplatelet gene SNPs, their haplotypes and G × E interactions on premature coronary artery disease - Takeaways - MDSpire

Several antiplatelet gene SNPs, their haplotypes and G × E interactions on premature coronary artery disease

  • By

  • Zhong-Hai Bi

  • Si-Cong Liu

  • Ying-Hong Weng

  • Ji-Yi Chen

  • Si-Yao Li

  • Xiao-Qun Lin

  • Yan-Li Liu

  • Liu Miao

  • June 29, 2026

  • 0 min

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  • 1

    The study investigates the impact of SNPs and haplotypes in antiplatelet drug metabolism genes on premature coronary artery disease risk.

  • 2

    1,108 participants were enrolled, including PCAD patients and controls, with twelve SNP loci genotyped for analysis.

  • 3

    Significant genotype and allele frequency differences were found for specific SNPs, with some associated with increased PCAD risk.

  • 4

    Haplotype analysis revealed protective and risk-associated haplotypes related to CYP2C19 and other genes affecting PCAD.

  • 5

    GMDR analysis identified significant gene-gene and gene-environment interaction models influencing PCAD risk.

Original Source(s)

Several antiplatelet gene SNPs, their haplotypes and G × E interactions on premature coronary artery disease

  • by Zhong-Hai Bi, Si-Cong Liu, Ying-Hong Weng, Ji-Yi Chen, Si-Yao Li, Xiao-Qun Lin, Yan-Li Liu, Liu Miao

  • June 29, 2026

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