Case Report: Repigmentation and complete hair regrowth in an 11-year-old preadolescent with alopecia totalis treated with a JAK inhibitor - Takeaways - MDSpire

Case Report: Repigmentation and complete hair regrowth in an 11-year-old preadolescent with alopecia totalis treated with a JAK inhibitor

  • By

  • Yanhong Jia

  • Xue Wang

  • Yuanxiang Liu

  • Zigang Xu

  • Bin Zhang

  • July 16, 2026

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  • 1

    An 11-year-old girl with alopecia totalis achieved complete hair regrowth and repigmentation after treatment with JAK inhibitors.

  • 2

    The patient initially received baricitinib for seven months, resulting in a SALT score of 65% with predominantly white and gray hair.

  • 3

    Switching to ritlecitinib at 50 mg/day led to black hair emergence at six weeks and complete regrowth and repigmentation at six months.

  • 4

    The Family Dermatology Life Quality Index score improved from 18 to 4, indicating enhanced quality of life during treatment.

  • 5

    No significant adverse effects were reported during 12 months of ritlecitinib therapy, with stable laboratory test results.

Original Source(s)

Case Report: Repigmentation and complete hair regrowth in an 11-year-old preadolescent with alopecia totalis treated with a JAK inhibitor

  • by Yanhong Jia, Xue Wang, Yuanxiang Liu, Zigang Xu, Bin Zhang

  • July 16, 2026

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